305 New shampoo targeting dry dandruff: Evaluation program and results

Introduction: Dry dandruff (DD) is in the form of small, whitish flakes, not adherent to scalp. Shampoo was developed for DD and formulated according requirements 'conscious care' with 85% natural ingredients. Objective: Clinical studies were designed assess its tolerance, efficacy sensoriality clinical, auto-assessment scoring, instrumental, pharmaco clinical methods an in-use test. Material methods: The vivo carried out on a total panel 121 subjects corresponding target product. First, use tolerance under dermatological control investigated 3 weeks (W). Efficacy persistence evaluated 8 W follow anti-dandruff-efficacy, scalp itching discomfort measure hydration (HI), Trans Epidermal Water loss (TEWL) pH Scalp microflora analysed by NGS sequencing from swabs sampled after 2 4 W. respect skin barrier explants. Consumer test 3W cosmetic acceptability efficacy. Results: results showed very good decrease dandruff, scores. HI increased at W2. PH TEWL did change significantly. Regarding microbiome, increase mycobiota diversity significant W2 bacteria population observed. integrity also shown. Cosmetic qualities appreciated. Conclusion: new anti-dandruff shampoo displays soothing effects that are persistent while respecting efficay. microbiota rebalanced, reflecting strong relation between disorders flora. All this evidence provides consumer quality product well tolerated, effective line expectations naturality.